Free shipping on modded consoles!
Picofly modifies the behavior of the Switch, turning a "child's toy" into a modestly specced, well priced touchscreen tablet with detachable controllers.
A modded Switch is a long matured platform capable of more than most people expect. By modding, the device is potentially capable of:
The Picofly thread on GBATemp has up to date technical info:

The Picofly mod is a kit, a collection of parts that work together on all variants of the original Switch (not Switch 2).
The Picofly kit uses two FPC cables and one custom PCB with a controller chip called a Raspberry Pi. The controller chip convinces the Switch to run custom code installed to your microSD.
The kit requires precise soldering on parts as small as 0.3 mm and fitment may require modding of fiberglass, metal, or plastic internals.
Because of the method used, the kit does not need a "blank" or reset device to start from, you can keep your saves.

Yes.
The only danger comes from installation of the hardware. Amateur soldering and modification of the thin and delicate circuit board can ruin it. We offer a mod recovery service if your own mod attempt broke something.
(Sagebrush Repair has over 16 years repair experience, good job finding us. 🎖️)

No.
The console will effectively have two main modes of use after modding: modded and stock, aka CFW and OFW.
The above bullet points are always true until you do something reckless in advanced boot modes (see "Misc" below).
(Important information for owners using Hekate)
Combine these terms and you get "sysMMC OFW" aka Stock. This is commonly shortened to just OFW and means a normal out of the box boot mode using the soldered, physical chip. The same as unmodded.
Combining different terms nets you "emuMMC CFW" aka "modded". This is commonly shortened to just CFW and means running a modified version of HOS from a microSD card.
You'll notice there may be other combinations of terms possible. There are, and the resulting boot modes can be ignored by most people. There's more about the other modes below.

SD recommendations:
Community Resources:
Misc:
Sagebrush Repair